Dextromethorphan Hydrobromide

    DESCRIPTION

    Dextromethorphan Hydrobromide is a practically odourless, white to almost white crystalline powder with a bitter taste. It melts at about 125°C with decomposition.

    Formula
    (Empirical)
    C18H25NO·HBr·H2O
    Chemical name(+)-3-methoxy-N-methyl-morphinane hydrobromide monohydrate; 3-methoxy-17-methyl-9α, 13α, 14α-morphinane hydrobromide monohydrate
    SynonymsDextromethorphan hydrobromide
    AppearanceWhite to almost white crystalline powder
    Appearance of solution
    (5% in alcohol)
    Clear and Colourless
    UsageFor antitussive pharmaceutical preparations
    DosageSummary of approved dosages:
    Adult:
    Every 4hrs: 10-20mg
    Every 6-8 hrs: 30mg
    Max for 24hrs: 120mg

    6-12 years
    Every 4hrs: 5-10mg
    Every 6-8hrs: 15mg
    Max for 24hrs: 60mg

    2-6 years
    Every 4hrs: 2.5-5mg
    Every 6-8hrs: 7.5mg
    Max for 24hrs: 30mg

    Under 2 years: Consult a doctor
    Identity Corresponds
    CAS No.6700-34-1
    EINECS No.204-750-1
    Molecular weight
    (Mass)
    370.33g/mol

    SPECIFICATIONS

    Assay
    (on anhydrous substance)
    99.0 to 101.0%
    SolubilitySparingly soluble in water (Approx 1.5g/100ml), Soluble in alcohol and glycerol and practically insoluble in ether.
    Particle size10% of the particles: Max 110μm
    50% of the particles: Max 200μm
    90% of the particles: Max 300μm
    Water4.0 to 5.5%
    pH
    (1% aqueous solution)
    5.2 to 6.5
    Acidity or Alkalinity Passes test
    Heavy metalsMax 20 ppm
    Sulphated ash
    (residue on ignition)
    Max 0.1 %
    Related SubstancesPasses test
    Specific Optical Rotation325nm, 25°C (c=1.8 in water): within 1% of standard (on anhydrous substance)
    589nm, 20°C (c=2.0in 0.1 N HCl): +28° to +30° (on anhydrous substance)
    StabilityFairly stanle in air, heat and humidity, but is sensitive to light (decomposition). Aqueous solutions are stable at a pH between 4 and 6, but should be protected from light.
    N,N-DimethylanillineMax 10 ppm
    Phenolic CompoundsPasses test
    StorageStore in original containers and at a temperature below 25°C.
    Shelf life4 years from date of manufacture if storage conditions observed.


    Direct Food Ingredients will ensure that any material supplied this specification will confirm to the above physical and chemical properties. However, we have no control over the use of the material and can accept no responsibility for problems caused by the customer's failure to ensure the material supplied is suitable for the intended use.

    This specification has been last modified on Thu 19 May 2011 (593)

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